Charcot disease can be a serious neuropathic condition (a nerve problem that causes pain, numbness, tingling, swelling, or muscle weakness in different parts of the body) that may affect people of all ages. It may occur anywhere in the body, but often affects the lower extremities. Charcot in the foot or ankle is defined by a sudden softening of the bones that can trigger an avalanche of problems including joint loss, fractures, arch collapse, deformity, and ulcer formation. If left untreated, Charcot complications can lead to amputation.¹

Charcot can be found in different areas of the lower leg, but most commonly affects the midfoot and ankle.²

As Charcot foot progresses, the bottom of the foot can become rounded, bulging like the hull of a ship.¹ Because of its appearance, your healthcare provider may refer to this as a "rocker bottom".

There is still a lot to learn about what leads to Charcot in the foot and ankle, but it is thought to be caused by repetitive injury or trauma that builds-up over time. It's an unfortunate cycle. The continued stress placed on the foot through this repeated trauma ends up dulling the nerves in the foot, which in turn makes the condition worse because the pain goes unnoticed. The longer someone has neuropathy (significant nerve damage), the higher the risk they have for developing Charcot in the foot and ankle.³

Charcot in the foot and ankle is often the result of uncontrolled diabetes and is sometimes referred to as "diabetic foot"⁴:

• First, poor blood supply to the nerves dulls sensation in the foot, making diabetics less likely to feel foot injuries.

• Second, the lack of blood being supplied to the skin and the foot makes the healing process more difficult. Because of this sensation, diabetic patients are more likely to get wounds and the wounds they do get are less likely to adequately heal. Unattended wounds allow bacteria to enter the foot, leading to diabetic foot infections.

• If you are suffering from neuropathy, you may even sustain fractures or dislocations in the foot without even realizing it.

Understanding the origins of your Charcot foot is important to understanding your treatment next steps. Beyond diabetes, Charcot in the foot and ankle can develop through sprains or broken bones if the injury goes untreated due to a lack of sensation caused by nerve damage. Obvious traumatic events such as falls and injuries sustained in accidents can be contributing factors.⁵ Other causes include alcoholism or drug abuse, infection, spinal cord injury, various neurological diseases and conditions, steroid intake, and heavy-metal poisoning.⁶

The telltale signs of Charcot often come on suddenly, making management tricky.¹ Some common symptoms include:

• Warmness to the touch, redness, and swelling in the foot or ankle.³

• Persistent pain or soreness

• Visual deformity, such as the "rocker bottom" appearance to the foot

• Loss of protective sensation⁵

• Ulcer formation, especially those slow to heal

Ulcers that form as result of a Charcot deformity in the foot or ankle are a major risk factor for amputation and should be treated promptly.

Charcot in the foot and ankle can be difficult to diagnose, and misdiagnosis is not uncommon.¹

Because diagnosis can be difficult, a careful examination from a qualified foot and ankle surgeon is often necessary to confirm the condition. In addition to the examination, this expert will likely conduct a detailed review of your medical history and evaluate other factors that may contribute to the condition, including:

• Resistance to antibiotic treatments

• X-rays or other diagnostic imaging that show disruption to your body

• Recurring or longstanding wounds

While Charcot is not reversable, the speed at which the disease progresses may be managed or slowed, and more serious outcomes may be avoided if addressed by a healthcare provider in a timely manner. Foot and ankle specialists may utilize the latest technologies and medical techniques, while leaning on the expertise from your team of specialists, to work to prevent amputation.